D-tagatose Powder

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 D-Tagatose is a naturally occurring rare monosaccharide, which is a ketose form of galactose and an epimer of fructose. The sweet taste characteristics are similar to sucrose, and the heat generated is only one-third of that of sucrose, so it is called a low calorie sweetener. Tagatose has excellent nutritional characteristics such as low calorie value, zero glycemic index, blood glucose passivation, non caries properties, prebiotic effects, and antioxidant activity.

 It is a type of lactose that is hydrolyzed from lactose to obtain galactose (as lactose is a reducing disaccharide formed by the combination of galactose and glucose). Galactose is an isomer of glucose, which is also a hexose. It is then isomerized by an isomerase to convert galactose into a keto containing hexahexulose.

 

 Character: A hexaketose, which is an epimer of fructose. Molecular formula C6H12O6, relative molecular weight 180.16. There are two forms, left-handed and right-handed, commonly used as left-handed D-tagatose. White odorless crystalline powder, sweet in taste, with a sweetness of 92% of the same amount of sucrose, but producing only 1/3 (1.5 kcal/g) of sucrose. Its melting point is 132-135 ℃, and its 1% aqueous solution [alpha] D20-6 ± 1 ° (c=5, H2O) is soluble in water with a solubility of 58.3% (20 ℃) and 62% (30 ℃), almost insoluble in ethanol and methanol. Relatively stable to heat, with a glass transition temperature of 15 ℃, easy to crystallize, low moisture absorption, and strong moisturizing properties. Strong acid resistance, stable within the range of pH 2-7. Easy to undergo caramelization reaction and Maillard browning reaction. Natural tagatose is mainly present in dairy products such as yogurt and milk powder.

Specifications：

Molecular structure data：
1. Molar refractive index: 37.15
2. Molar volume (m/mol): 102.4
3. Isometric volume (90.2K): 317.1
4. Surface tension (dyne/cm): 91.8
5. Polarization rate (10cm): 14.73

Characterization map：
1. D - (-) - Tagatose mass spectrometry (MS)

2. D - (-) - Tagatose NMR (13CNMR)

3. D - (-) - Tagatose NMR (1HNMR)

4. D - (-) - Tagatose infrared spectrum (IR1)

5. D - (-) - Tagatose infrared spectrum (IR2)

Computational Chemistry Data：
1. Reference value for hydrophobic parameter calculation (XlogP): -2.8
2. Number of hydrogen bond donors: 5
3. Number of hydrogen bond receptors: 6
4. Number of rotatable chemical bonds: 1
5. Topological molecular polarity surface area (TPSA): 110
6. Number of heavy atoms: 12
7. Surface charge: 0
8. Complexity: 162
9. Isotope atomic number: 0
10. Determine the number of atomic structure centers: 3
11. Uncertain number of atomic structure centers: 1
12. Determine the number of chemical bond stereocenters: 0
13. Uncertain number of chemical bond stereocenters: 0
14. Number of covalent bond units: 1

Physiologic Function：

1. Low calorie
The absorption rate of D-tagatose in the human small intestine is only 20% -25%, and most of the tagatose is broken down and metabolized by bacteria after entering the large intestine. D-tagatose can be metabolized through the tagatose-6-phosphate pathway, which exists in some microorganisms and is not present in higher animals. The absorption rate of D-tagatose in the small intestine is very low. The part that is not absorbed by the small intestine reaches the large intestine and is completely fermented by the microorganisms in the intestine, producing a large amount of short chain fatty acids that are almost completely absorbed and metabolized. These short chain fatty acids play an important role in maintaining the normal function of the large intestine and the morphology and function of colonic epithelial cells, and they also affect the types and physiological status of gut microbiota. The fermentation process produces relatively low energy, and with the increase of microbial excreta, there is also a loss of some energy. Related studies have also shown that D-tagatose can inhibit colon cancer and intestinal pathogenic bacteria. Therefore, the energy produced by the breakdown metabolism of tagatose is much lower than that of sucrose. Replacing sucrose with tagatose in the diet can effectively reduce the occurrence of obesity.

2. Reduce blood sugar
Research has shown that there is no significant change in blood glucose and insulin levels after ingestion of tagatose in the body. In addition, tagatose can also inhibit the absorption of glucose by the small intestine, which can effectively reduce the blood sugar increase caused by glucose intake in diabetes patients, and has an auxiliary therapeutic effect on type II diabetes patients.

3. Improve gut microbiota
D-tagatose is selectively fermented by some microbial communities in the colon, promoting the growth of probiotics and making it a good prebiotic. At the same time, the large amount of beneficial short chain fatty acids produced by the fermentation of tagatose have a good effect in inhibiting colon cancer, inhibiting intestinal pathogenic bacteria, and promoting the growth of beneficial bacteria. Therefore, D-tagatose can improve gut microbiota and maintain intestinal health.The sweetness is 250-450 times that of sucrose, with a slight astringency. Steviol A glycoside has a clear bitterness and a certain degree of astringency and menthol taste, and its taste characteristics are slightly worse than steviol disaccharide A. It is moderately delicious, with less aftertaste after pure tasting, and is the natural sweetener closest to sugar. But when the concentration is high, there will be a strange odor.

4. Anti caries teeth
D-tagatose is similar to polyols in protecting teeth. Due to its low acid production in the oral cavity, it does not lower the pH value of dental plaque, effectively preventing the occurrence of dental caries and enamel corrosion, and does not produce the diarrhea phenomenon of polyols. It can be used in toothpaste and chewing gum.

5. Promoting blood health
Tagatose can enhance key blood factors such as red blood cell count, prothrombin time, activated partial thromboplastin time, coagulation factors, etc., thereby promoting blood health. 

Application：

In 2001, FDA confirmed the safety of D-tagatose and approved it as a GRAS product, which can be used as sweetener in the food and beverage industry as well as in pharmaceutical formulations. In the same year, the JECFA of the United Nations and the World Health Organization recommended D-tagatose as a kind of new low calorie sweetener that can be used as food additive.

1. Used for food
The safety and production of tagatose have been approved by more than 30 countries including China, the European Union, the United States, Australia, New Zealand, and South Korea, as well as WHO/FAO and the International Codex Alimentarius Commission, with no restrictions on its daily intake and use.
2. Used for pharmaceuticals
Tagatose has completed the phase III clinical trial for the treatment of type II diabetes and the preclinical trial of anti triglyceride as authorized by the US FDA.
3. Other uses
Tagatose has been approved by the US FDA as a medicinal excipient for throat moistening tablets, over-the-counter diabetes cough syrup, chewing antibiotic tablets, non steroid anti-inflammatory drugs and paediatric drugs. The US FDA approves tagatose as a substitute for sucrose and other sweeteners in toothpaste, mouthwash, and cosmetics.

Market Prospect ：
1. Food
Sucrose is the food ingredient in the diet that is most closely related to the prevalence of modern chronic diseases such as cardiovascular and metabolic diseases. Replacing sucrose with tagatose not only maintains the taste of sucrose, but also brings health benefits to diet in preventing and treating modern chronic diseases. Tagatose is a healthy sugar suitable for all types of food and for everyone to consume.
2. Health products and medicines
Tagatose can also be used as a health product and medicine (ingredient) for the prevention and treatment of chronic diseases such as cardiovascular and metabolic diseases:
Tagatose has low calorie, zero glycemic index, anti hyperglycemic ability and catalytic properties to promote the transfer of glucokinase from nucleus to cytoplasm, so that it can be used to prevent and treat metabolic syndrome, abnormal glucose tolerance, abnormal blood lipids, obesity, type II diabetes, insulin resistant diseases, coronary heart disease and atherosclerosis;
The prebiotic properties of tagatose enable it to selectively promote the growth and reproduction of probiotics, which is beneficial for intestinal health and prevents colon cancer;
The anti biofilm properties of tagatose enable it to be used for the prevention and inhibition of diseases caused by oral and in vivo biofilm formation;
Tagatose can improve the characteristics of mammalian blood factors, making it suitable for treating anemia and hemophilia, and promoting blood health;
The antioxidant properties of tagatose enable it to be used for the prevention and treatment of many chronic diseases;
Tagatose promotes healthy fetal development and can be used to improve the development of human fetuses.
3. Non food and non pharmaceutical products
Tagatose can improve the synergistic effect of multiple strong sweeteners on sweetness, enabling it to excel in improving and enhancing the flavor and taste of food and beverages. Tagatose can be used as a excipient in pharmaceutical formulations and cosmetics, as well as an additive in detergents and an intermediate in the synthesis of optically active compounds.

OEM&ODM Compound Sweetener:

We are a professional manufacturer of natural sweeteners. In addition to supplying regular D-Tagatose specifications, we can also provide you with the best sweetener solution according to your needs. At the same time, we can also provide composite and alternative sugar solutions based on your formula.

Certificates：

Package：

5 Grams to 2kg Packaging: Alu-bag	5 KG/Al-Tin Packaging: 2 pcs Alu-tin with box	25 KG, Packaging: Drum (54*37*37cm)=0.07CBM N.W:25KG / G.W:28KG

Delivery：

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