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(R)-(+)-Lipoic Acid Powder

<p>Cas: 1200-22-2</p> <p>Molecular formula: C8H14O2S2</p> <p>Molecular weight: 206.33</p> <p>Appearance: White or light yellow, odorless powder or crystal</p> <p>Solubility in water: Insoluble in water, soluble in phenylethanol, chloroform, glycerol, and lipids</p> <p>Melting point: 46~49℃</p> <p>Purity:99.00% Min( by HPLC)</p> <p>Production capacity: 1000 tons/year</p>

Product Description

(R)-(+)-Lipoic Acid Powder

 

(R)-(+)-Lipoic Acid Powder

R-lipoic acid, also known as D-lipoic acid, (R)-(+)-Thioctic acid,(R)-(+)- 1,2-Dithiolane-3-pentanoic acid, chemical name: (R) - (+) -1,2-dithiopentanyl-3-valeric acid, (R) - (+) -5- (1 ', 2' - dithiocenyl-3 '-) - valeric acid, is a white or light yellow, odorless powder or crystalline substance.

 

Vitamin drugs, are used for acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver, diabetes, people with acquired immune deficiency, AIDS, cowhide moss, eczema, burns, skin cancer, multiple sclerosis, Parkinson's disease, neurological diseases, rheumatism, rheumatoid arthritis, lupus erythematosus, scleroderma, autoimmune diseases, cataracts, other ophthalmic diseases, heart disease, stroke, arteriosclerosis, treatment and therapeutic health care of acute and chronic hepatitis, cirrhosis, hepatic coma, fatty liver and other diseases.


Its dietary supplement products include powders, mixtures, tablets, hard gel capsules, soft gel capsules, and can also be applied to functional foods such as beverages, candies, bread, and dairy products. In order to better manufacture different varieties of dietary supplements and better apply ALA to the manufacturing of different types of functional foods, it is necessary to store them at temperatures below 40 ℃ in a dark place (UV).

 

Specifications:

Product Name (R)-(+)-Lipoic acid,(R)-(+)-Thioctic acid,(R)-(+)- 1,2-Dithiolane-3-pentanoic acid
Chemical Name (R) - (+) -1,2-dithiopentanyl-3-valeric acid, (R) - (+) -5- (1 ', 2' - dithiocenyl-3 '-) - valeric acid
Appearance White or light yellow, odorless powder or crystal
Molecular Formula C8H14O2S2
Molecular Weight 206.33
Purity 99.00% Min( by HPLC)
Solubility  Insoluble in water, soluble in phenylethanol, chloroform, glycerol, and lipids
Melting Point 46~49℃
Optical Rotation +104 ° (c=0.88, benzene, 23 ° C)
Packaging 5kg/25kg cardboard drum packaging, lined with polyethylene bags and kraft paper bags.
Storage It should be sealed and shaded, stored in a dry, cool, and well ventilated place at low temperature (<30 ℃).

 

Quality Index:

Character White or light yellow, odorless powder or crystal
Distinguish Meets the requirements
Melting Point 46~49℃
Cyclohexane 0.388% Max
Optical Rotation +100°~+120°
Dry Weight Loss 0.5% Max
Burning Residue 0.1% Max
Heavy Metal 10ppm Max
Total Number of Microorganisms 1,000 per/g Max
Mold and Yeast 100 per/g Max
Escherichia Coli Negative
Salmonella Negative
Content 99.00% Min( by HPLC)

 

Method of Production :

There are many methods for preparing R-lipoic acid through chemical synthesis in the world, and there are mainly three types of methods:
1. Starting from 6,8-dichlorooctanoic acid ethyl ester, racemic α - lipoic acid was obtained through thiolation, cyclization, and hydrolysis (U.S. 27924061957); U.S.3223712,1965), The separation agent was used to obtain R-lipoic acid, and the yield of this step was only 45%. And S-lipoic acid is not easily converted to R S-type or R-type waste half of resources and make R-lipoic acid expensive.
2. Using 6,8-dihydroxyoctanoic acid methyl ester or 6-hydroxy-8-chlorooctanoic acid methyl ester as the starting material, methanesulfonate is prepared, and then stereoselective to R-lipoic acid (U.S. 5869713), G.Bringmann, J.Paust Z.Naturforschung 54b,661-665,1999), But the process is relatively complex and it is not easy to obtain pure products.
3. Hydrolyze racemic 6,8-dichlorooctanoic acid ethyl ester into (±) dichlorooctanoic acid (DCA), salt with (-) ephedrine, split, thiolate, cyclize (Acker, etc.), J.Am.Chem.Soc., 76,6483,1954), This method can basically save costs, but about 50% of S - (-) -6,8-dichlorooctanoic acid is still not utilized, resulting in higher costs.
There are no detailed literature reports on the conversion of S - (-) -6,8-dichlorooctanoic acid to R - (+) -6,8-mercaptooctanoic acid and R-thiooctanoic acid.

 

Certificates:

Steviol Glycosides - Stevia Sweetener

Package:

Steviol Glycosides - Stevia Sweetener Steviol Glycosides - Stevia Sweetener Steviol Glycosides - Stevia Sweetener

5 Grams to 2kg

Packaging: Alu-bag

5 KG/Al-Tin

Packaging: 2 pcs Alu-tin with box

25 KG, Packaging: Drum

(54*37*37cm)=0.07CBM

N.W:25KG / G.W:28KG

 

Delivery:
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