Cas No.: 3211-76-5
Product Description
L-(+)-Selenomethionine CAS: 3211-76-5
L-Selenomethionine is the predominant food form of selenium with antioxidant activity. L-Selenomethionine has been shown to increase the activity of glutathione peroxidase in endothelial cells. It may be chemoprotective against certain cancers. Nutritional supplements in health care products.
CAS number:3211-76-5
Molecular Formula:C5H11NO2Se
Product Purity:≥98%
Structural Formula:
L-selenomethionine is biologically active in humans and many other life forms. the primary value of L-selenomethionine in nutraceuticals is to provide a bioavailable form of selenium, an essential nutrient. l-selenomethionine may be more readily absorbed than selenite, an inorganic form of selenium that is commonly used in nutraceuticals. A clinical trial showed that L-selenomethionine was absorbed 19% more than selenite.
Selenium plays a critical role in many biochemical reactions, particularly as a cofactor in reducing antioxidant enzymes. l-Selenomethionine oxide is readily oxidized, enabling it to reduce the levels of reactive oxygen compounds. These compounds include free radicals that can cause cellular damage.
The best dietary sources of selenium include grains, legumes and soybeans, with Brazil nuts usually having the highest selenium content. However, the selenium content of plants usually depends more on the amount of selenium in the soil than on the type of plant. Other sources of selenium include fish, crustaceans, organ meats, mushrooms and eggs. The adult human body contains up to 20 milligrams (mg) of selenium, and the minimum daily requirement for selenium for adults is at least 55 micrograms (mcg).
Chemical Properties |
Solid |
Uses |
A compound was shown to increase the expression of glutathione peroxidase |
Uses |
Seleno-L-methionine has been used: in toxicity studies in Japanese Medaka embryos to study its effects on selenium status indicators in pregnant long-tailed macaques (Macaca fascicularis) to label proteins for single wavelength anomalous dispersion (SAD) phasing |
Definition |
ChEBI: The L-enantiomer of selenomethionine. |
General Description |
Seleno-L-Methionine (SeMet), an organic form of selenium is found in Cupriavidus metallidurans. |
Biochem/physiol Actions |
Seleno-L-Methionine (SeMet) is capable of repressing atopic dermatitis (AD)-like skin lesions. It can also prevent the expression of total immunoglobulin E (IgE) and interleukin 4 (IL-4). It can cause ecotoxicity as it is absorbed by fish through diet. |
As a source of selenium, L-selenomethionine has many specific uses. The most common reasons for taking L-selenomethionine in supplements include management of the thyroid, heart, immune system and healthy cholesterol levels.
Some studies show that selenium may help to support thyroid function, which can contribute to a general feeling of well-being. The regimen in these studies consisted of 200 mcg of selenium per day.
Selenium may support white blood cell activity, which helps to fight off infections.
An intake of up to 200 mcg selenium per day can help to maintain a healthy cholesterol profile, according to one study. The subjects in this study had low selenium levels at the beginning of this study.
Selenium supplements may help to manage blood clotting, which is useful for maintaining heart health.
Raw materials |
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The relative abundance of selenium in the soil and its low nutritional requirements means that selenium deficiency is rare in humans. This is likely to occur in patients with severely impaired gastrointestinal function, which can occur after gastrointestinal bypass surgery or in very elderly patients. The most common signs that you may need L-selenomethionine include poor heart function and cartilage degeneration. Systemic fatigue and a weakened immune system may also mean that you may benefit from L-selenomethionine.
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